Patterdale Terrier Club of America December 2024
15
Primary Lens Luxation
By Lynde Capogreco
The lens is the transparent structure within the eye that focuses light on the retina, the area where vision occurs. It
is a flattened sphere held in place by tiny ligaments around its circumference. There are two main conditions that
affect the lens: cataract formation and lens luxation. Lens luxation affects many breeds of dogs, particularly the
terrier breeds, including Patterdale Terriers. Luxation occurs when the support ligaments of the eye weaken or
break, causing the lens to dislocate from its normal position. The lens can fall backward into the eye, known as
posterior luxation, where it rarely causes discomfort. It can also fall forward into the eye, called an anterior
luxation, where it blocks the drainage fluid from the eye resulting in glaucoma or increased intraocular pressure.
This condition is extremely painful and can cause permanent blindness. The only effective treatment for lens
luxation is surgical removal of the displaced lens. If surgical removal of the lens is not possible, then enucleation
(removal of the entire eye) may be performed to alleviate pain from the condition. Primary Lens Luxation (PLL)
because of the disease mutation, although they might develop PLL due to other causes, such as trauma or the
effects of other, unidentified mutations.
CARRIER (N/PLL genotype): These dogs have one copy of the mutation and one normal copy of DNA. The
majority of carriers do not develop PLL during their lives, but a small percentage do. It is currently unknown why
some carriers develop the condition whereas the majority do not, but it is advised that all carriers have their eyes
examined by a veterinary ophthalmologist every 6- 12 months from the age of 2, throughout their entire lives.
GENETICALLY AFFECTED (PLL/PLL genotype): These dogs have two copies of the mutation and will almost
certainly develop PLL during their lifetime. It is advised that all genetically affected dogs have their eyes
examined by a veterinary ophthalmologist every 6 months, from the age of 18 months, so the clinical signs of PLL
are detected as early as possible.
Breeding Advice:
Research has demonstrated that the frequency of the PLL mutation is extremely high in the PLL-affected breeds.
This means that allowing only CLEAR dogs to breed could have a devastating effect on breed diversity and
substantially increase the likelihood of new inherited diseases emerging. Therefore, it is strongly advised for
breeders to consider all their dogs for breeding, regardless of their PLL genotype. GENETICALLY AFFECTED and
CARRIER dogs can be bred with, but should only be bred to DNA tested, CLEAR dogs. All puppies from any litter
that has at least one CARRIER parent should be DNA tested, so that the CARRIERS can be identified and followed
clinically throughout their lives. This practice should be followed for at least one or two generations, to allow the
PLL mutation to be slowly eliminated from the population without severely reducing the genetic diversity of
breeds at risk.
For more information about PLL, the testing process, and test pricing, please visit:
https://vgl.ucdavis.edu/test/primary-lens-luxation#Price
https://www.pawprintgenetics.com/pricing/#tab_individual
https://embarkvet.com/products/dog-health/health-conditions/primary-lens-luxation/
https://www.ofora.com/lens-luxation/
is secondary to other conditions such as uveitis, glaucoma, cataract,
cancer of the eye, or trauma, but in some dogs, it is an inherited eye
condition. The disease is inherited in an autosomal recessive fashion,
so both males and females are equally affected. PLL appears
spontaneously between 3-8 years although both eyes are not
necessarily affected at the same time. Dogs with one copy of the
mutation most often show no sign of PLL but can, on occasion,
develop the disease. Breeding between two carriers is expected to
produce 25% affected offspring. Testing for PLL assists owners and
breeders in identifying affected and carrier dogs, and breeders can
use results from the test as a tool for selection of mating pairs to
avoid producing affected dogs. Genetically tested dogs will receive
one of the designations below:
CLEAR (N/N genotype): These dogs have two normal copies of
DNA. Research has demonstrated clear dogs will not develop PLL
Patterdale Terrier Club of America